With the occurrence of obesity, the immune cells in adipose tissue infiltrate and produce inflammatory factors, such as tumor necrosis factor-α (TNF-α), interleukin (IL), and C-C motif chemokine ligand 2 (CCL2), promoting local or systemic inflammatory responses [24, 25]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.