Most importantly, three genes, Slco1a1, Angptl4, and Hmgcs2 displayed a consistent change across the two models, which was further verified in db/db mice, implying an important role of Slco1a1, Angptl4 and Hmgcs2 as candidate targets for the diagnosis and intervention of DKD. Here, HMGCS2 is linked to diabetic kidney disease.