The results showed that mRNA expression of EZH2, G6PD, LGALS3 and PSMD14 was elevated in cancer tissues from HCC patients compared with normal gastric cancer parietal tissues, and the difference was statistically significant in the parietal cancer, which may suggest EZH2, G6PD, LGALS3 and PSMD14 as potential biomolecular markers for HCC.However, there are some shortcomings in our study. The gene discussed is EZH2; the disease is gastric cancer.