As shown in Table 3, some ‘dark’ genes were enriched into the biological processes associated with COVID-19 (Supplementary Table S2), e.g. ‘positive regulation of fibroblast proliferation’ (GO:0048146), ‘regulation of interleukin-10 secretion’ (GO:2,001,179), ‘protein glycosylation’ (GO:0006486), ‘immune response’ (GO:0006955), ‘RNA binding’ (GO:0003723) and others in Gene ontology (Fig. 5C-E). The gene discussed is IL10; the disease is COVID-19.