To sum up, our study revealed that IGF2BP3 acts as an oncogene to promote NPC metastasis by maintaining NOTCH3 mRNA stability via suppressing CCR4-NOT complex-mediated deadenylation, thus leading to constant activation of the Notch3 signaling pathway and enhancing tumor metastasis. The gene discussed is IGF2BP3; the disease is nasopharyngeal carcinoma.