Collectively, our findings highlighted an important role of IGF2BP3 in NPC metastasis and elucidated the precise mechanism of IGF2BP3-mediated post-transcriptional regulation on NOTCH3, identifying IGF2BP3 as a novel prognostic biomarker and potential therapeutic target in NPC metastasis. This evidence concerns the gene IGF2BP3 and nasopharyngeal carcinoma.