Notably, silencing IGF2BP3 potently impaired the stemness properties in NPC cell lines and lung metastasis in tumors, and these effects were abrogated by NOTCH3 overexpression, suggesting that IGF2BP3 promotes tumor metastasis through Notch3 pathway (Supplementary Fig. 4H, I and Fig. 4K). The gene discussed is NOTCH3; the disease is nasopharyngeal carcinoma.