Ectopically expressed IGF2BP3 expression in NPC cells identifies and binds with m6A-modified NOTCH3 mRNA to facilitate its stability and inhibit deadenylation-mediated mRNA decay, which constantly activates the Notch signaling pathway and enhances the tumor-initiating activity, eventually promoting tumor metastasis. The gene discussed is IGF2BP3; the disease is nasopharyngeal carcinoma.