IGHE and allergic disease: In addition, cross-reactivity of paprika proteins with latex (possible paprika contaminant), tomato, tobacco, grapes, mustard, kiwi, sesame, avocado, wheat, maize, banana, chestnut, hazel, molds, meadow plants, and even cattle, crab and fishes is possible and should be taken into account in allergy diagnosis, especially in the cases of idiopathic and non-IgE-mediated anaphylaxis, without exceeding norms of specific IgE antibodies.