NRXN1 and schizophrenia: The only single gene disrupting CNV that is currently implicated in schizophrenia involves non-recurrent exonic deletions of NRXN1. Individually, the 12 schizophrenia-associated CNVs occur in 0.015%–0.64% of cases [21] but confer strong risks for schizophrenia in individual carriers, with estimated odds ratios ranging between 1.8 and 81.2 [20, 21] (Fig. 1).