In the KEGG category, the target genes were mainly involved in fluid shear stress and atherosclerosis, insulin resistance, sphingolipid signaling pathway, HIF-1 signaling pathway, yersinia infection, T cell receptor signaling pathway, Toll-like receptor signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, etc. (Fig. 3D). Here, CD274 is linked to atherosclerosis.