The expression level of P4-135aa increased significantly in GBM cells transfected with MAPK6P4 ORF12, while no significant change in P4-135aa levels was observed in GBM cells transfected with an ORF with a nonfunctional ATG codon mutation (named MUT) (Fig. 2e). This evidence concerns the gene MAPK6P4 and glioblastoma.