We knocked down KLF15 using two specific shRNAs (Fig. S3.1 e) and found that knockdown of KLF15 significantly reduced the protein levels of VEGFR2 and VE-cadherin (Fig. 3h), and inhibited the proliferation, migration, invasion, and VM capacity of GBM cells (Fig. 3i–l). The gene discussed is KLF15; the disease is glioblastoma.