KLF15 directly binds to the promoter region of LDHA and promotes its transcription, which in turn modifies VE-cadherin and VEGFR2 through a newly discovered post-translational modification, lactylation, to increase the expression of VE-cadherin and VEGFR2 and promote the development of VM in GBM. This evidence concerns the gene LDHA and glioblastoma.