NeuroD is vital for maintaining cellular maturation and status33 and is not expressed in glial tumor cells.34,35 NCAM and TH play a crucial role in neurogenesis, differentiation, and survival, with their loss of function leading to nerve regeneration disorders.36–38 The up-regulation of these indicators suggests that MLL1 knock-down may impede SCAP differentiation into astrocytes and promote neurogenesis. This evidence concerns the gene NCAM1 and glioma.