Type 2 diabetes patients with high polygenic risk (N = 1008) had earlier onset of diabetes (58.5 years vs. 61.0 years, p = 5.2e-04) and were more likely to be on insulin therapy (42.6% vs. 30.5%, p = 1.2e-04) compared to type 2 diabetes patients with low polygenic risk (N = 321). Here, INS is linked to type 2 diabetes mellitus.