Functional studies were performed as well, results showed that CRISPR/Cas9-mediated KCNAB2-KO promoted NSCLC cell colony formation (Fig. 4C), proliferation (Fig. 4D), migration (Fig. 4E), invasion (Fig. 4F), and motility (Fig. 4G), which were examined by cell colony formation, EdU staining, “Transwell”, “Matrigel Transwell” and phagokinetic track motility assays, respectively. Here, KCNAB2 is linked to non-small cell lung carcinoma.