Given the evidence that SphK1/S1P triggers autophagy and causes neuronal harm to microglia during brain ischemia-reperfusion through a TRAF2-dependent mechanism [155], it is logical to assume that the stroke-protective effect of FTY720 involves the inhibition of neuronal autophagy via the S1P signaling pathway [30]. The gene discussed is MBTPS1; the disease is stroke disorder.