Application of paired spatial sequencing and scTCR-seq to murine models of aging and influenza infection later in the disease course may therefore improve our understanding of how the CD8 T cell repertoire changes with age and how CD8 TRM cells develop post-infection or vaccination, as these cells are critical for prevention of reinfection96 but also promote lung fibrosis in aged mice14. The gene discussed is CD8A; the disease is pulmonary fibrosis.