To explore whether OVX-stimulated FSH is implicated in ApoE4-mediated AD pathogenesis, we conducted OVX surgery in female ApoE3-TR and ApoE4-TR mice (4 months old), and half of the mice were treated with anti-FSH antibody or control IgG (200 μg per day, i.p.)4 days after OVX consecutively for 8 weeks. The gene discussed is APOE; the disease is Alzheimer disease.