To alleviate the concern regarding strong implicated in ovariectomy-elicited AD pathologies, we also include estrogen or estrogen + FSH in the ovariectomy-treated female ApoE4-TR mice and find that it fails to attenuate AD pathologies onset and progression in these mice (Fig. 6), suggesting that FSH but not estrogen is accountable for triggering AD pathologies. The gene discussed is BRD2; the disease is Alzheimer disease.