To assess whether FSH elevation accelerates AD pathology onset, we administrate FSH into both young male and female ApoE4-TR mice, and find that FSH activates C/EBPβ/δ-secretase signaling and prominently facilitates the NFT pathologies in the brain from both sexes as compared to vehicle control (Figs. 2 and 3). This evidence concerns the gene BRD2 and Alzheimer disease.