Given the close association between abnormal expression of ANRIL and endothelial cell injury, smooth muscle cell proliferation, migration, aging, and apoptosis, monocyte adhesion and proliferation, lipid metabolism disorders, and DNA damage, as well as its critical role in the development of atherosclerosis, ANRIL provides further insights for clinical diagnosis and prognosis. This evidence concerns the gene CDKN2B-AS1 and atherosclerosis.