An increasing number of studies in the literature indicate that long non-coding RNAs (lncRNAs) play important roles in many physiological and pathological processes, and several circulating lncRNAs have been applied as biomarkers for the diagnosis and prognosis of cancer.14, 15, 16, 17, 18, 19 The expression of ZFAS1, CFLAR-AS1, POU3F3, and GAS5 has been tested as biomarkers for the diagnosis and postoperative prognosis of different types of cancer.20 This evidence concerns the gene POU3F3 and cancer.