The differentiation of naïve CD4+ T cells into subtypes with different functions is important in immune defense, but dysregulation of this process can induce multiple inflammatory and autoimmune diseases, including autoimmune uveitis (1, 2), systemic lupus erythematosus (3), multiple sclerosis (4), and Crohn’s disease (5). This evidence concerns the gene CD4 and autoimmune uveitis.