STAT3 and familial pancreatic carcinoma: We observed that NT5E expression was associated with several gene sets linked to amoeboid migration and pancreatic cancer progression, such as transforming growth factor–β (TGF-β), KRAS, WNT, nuclear factor κB (NF-κB) and IL-6/JAK/STAT3 signaling, hypoxia, or EMT (Fig. 5B).