DSC2 and Arrhythmogenic right ventricular dysplasia: Most ARVC cases are associated with mutations in desmosomal genes, including plakophilin-2 (PKP2), desmoglein-2 (DSG2), desmocollin-2 (DSC2), plakoglobin (JUP), and desmoplakin (DSP) (Dalal et al., 2005).