For 16 ARVC patients of the two genotypes, PKP2 and GE, we analyzed VT induction in each personalized heart model to understand the arrhythmogenic mechanisms, and specifically, the contributions of structural remodeling and genotype-modulated EP alterations to sustaining VT reentrant circuits in ARVC. The gene discussed is PKP2; the disease is Arrhythmogenic right ventricular dysplasia.