This correlated with the pattern of pro-hypertrophic IGF-1R pathway activation in respective murine cardiac specimens as well as miR-378−/− hiPSC-CMs and HG-cultured miR-378a+/+ hiPSC-CMs that also showed increased size, and suggests miR-378a independent hyperglycemia-promoted hypertrophy. This evidence concerns the gene IGF1R and Hyperglycemia.