MPV17L and mitochondrial DNA depletion syndrome: M-LP/Mpv17L (Mpv17-like protein) was originally discovered in mouse kidney during screening for genes with age-dependent expression (Iida et al. 2000, 2001). M-LP shows high sequence homology to Mpv17 (Spinazzola et al. 2006), the product of the gene responsible for mitochondrial DNA depletion syndrome.