The multivariate logistic regression model revealed older age (OR 1.114, 95%CI 1.079–1.151, p < 0.001), presence of atrial fibrillation (OR 2.266, 95%CI 1.145–4.487, p = 0.019), smoking before stroke (OR 2.817, 95%CI 1.472–5.391, p = 0.002), visual deficits in hospital (OR 2.968, 95%CI 1.626–5.416, p < 0.001), in-hospital delirium (OR 2.887, 95%CI 1.433–5.813, p = 0.003), pre-hospital mRS (OR 1.525, 95%CI 1.172–1.984, p = 0.002) and higher in-hospital CRP levels (OR 1.011, 95%CI 1.003–1.020, p = 0.006) as independent risk factors of mortality five years after stroke. Here, CRP is linked to delirium.