Shapley values identified the most informative features during training and validation as CRP, mRS at admission, leukocyte count, HF, NIHSS at admission, sex, and diastolic BP followed by systolic BP, age, and HR while LF, LF/HF, SDNN, RMSSD and type of stroke (I63/I61) only had a marginal impact on model classification (Fig. 4). This evidence concerns the gene CRP and stroke disorder.