A recent study suggests that by transcriptomic analysis of circulating sEVs from CKD mice models as well as from CKD patients, possibly from endothelial cells, the calcification-protecting miRNAs that target VEGFA signaling in CKD-driven vascular calcification are lacking: miR-16-5p, miR-17-5p, miR-20a-5p, and miR-106b-5p [67]. The gene discussed is VEGFA; the disease is chronic kidney disease.