SORT1 and metabolic disease: It participates in the loading and transportation of extracellular vesicles, which can transport the calcification-promoting protein TNAP into EVs [238], and can also promote the transportation of sortilin into EVs to form EVs with high mineralization capacity by forming homodimers containing intermolecular disulfide bonds [239], thus promoting VC. Sortilin plays an important role not only in the pathogenesis of cardiovascular diseases but also in metabolic diseases and cancers [240].