In this research, we established a TSRlncRNA signature in glioma and 15 TSRlncRNAs that possess prognostic significance were identified, including AC010173.1, HOXA‐AS2, AC074286.1, AL592424.1, DRAIC, HOXC13‐AS, AC007938.1, AC010729.1, AC013472.3, AC093895.1, AC131097.4, AL606970.4, HOXC‐AS1, AGAP2‐AS1, and AC002456.1. The gene discussed is HOXA-AS2; the disease is central nervous system cancer.