APP and early-onset autosomal dominant Alzheimer disease: One case study for a Single dataset is shown below, where users select Organism: ‘Homo sapiens’, Study Type: ‘Single’, Tissue Type: ‘Brain’, Condition: ‘Alzheimer's disease’ and Pathway: ‘APP’ in the Pathway Search mode to obtain the cell−cell communication analysis results related to Alzheimer's disease (AD) mediated by the APP signalling pathway in humans.