The levels of Collagen I, Collagen III, ACTA2, and CTGF were all elevated in the MI groups compared with their corresponding sham groups (P <0.05,P<0.01), except those of Collagen III and ACTA2 between the KO-Sham group and the KO-MI group. This evidence concerns the gene ACTA2 and myocardial infarction.