SMAD3 and myocardial infarction: In our study, underTxnip-KI conditions, the levels of TXNIP, NLRP3, Cleaved Caspase-1/Caspase-1, IL1B, and TGFB1 and the p-Smad3/Smad3 ratio showed the most significant increase after MI, and collagen deposition and scar size were also most noticeable among the three MI groups.