In our study, underTxnip-KI conditions, the levels of TXNIP, NLRP3, Cleaved Caspase-1/Caspase-1, IL1B, and TGFB1 and the p-Smad3/Smad3 ratio showed the most significant increase after MI, and collagen deposition and scar size were also most noticeable among the three MI groups. This evidence concerns the gene TXNIP and myocardial infarction.