SMAD3 and myocardial infarction: The results derived from collagen detection suggested that the reduced deposition of Collagen I and Collagen III after MI might be associated with the inhibitory effect ofTxnip-KO on NLRP3 inflammasome activation and the subsequent reduced production of IL1B and less positive feedback on TGFB1/Smad3 signaling, whileTxnip knock-in aggravated post-MI collagen deposition by enhancing the TGFB1/Smad3 pathway and promoting NLRP3 inflammasome activation.