Compared with the WT-MI group, the KI-MI group showed significantly increased expressions of Collagen I, Collagen III, and CTGF (P<0.01), while the KO-MI group showed a significant decrease in these indices (P<0.01;Figure 3C‒F andFigure 4A‒C,E). This evidence concerns the gene CCN2 and myocardial infarction.