The differential and coproduction of MK and PTN by innate APCs can have different impacts on T and B cells under the conditions of tumors and infections, where the NAS TLRs have a major role in detecting the damage and pathogen-associated molecular patterns [36], particularly through TLRs 3, 7, 8, and 9 that do have different capacities in the induction of MK and PTN. The gene discussed is PTN; the disease is infection.