The NF-κB signaling cascade enhances the gene transcription of cytokines, promotes the expression of inflammatory factors, such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6), as important inflammatory factors affecting hepatic steatosis, are mainly responsible for the induction of neutrophil sequestration in the liver and directly mediate tissue injury (67). The gene discussed is TNF; the disease is fatty liver disease.