HIF1A and Hepatic fibrosis: Conversely, the use of HIF-1α inhibitors has been shown to improve liver fibrosis by downregulating suppressors of cytokine signaling (SOCS) 1 and 3, thereby inhibiting the activation of nuclear factor kappa-B (NF-κB) and phosphorylation of signal transducer and activator of transcription (STAT)3 (66).