The NF-κB signaling cascade enhances the gene transcription of cytokines, promotes the expression of inflammatory factors, such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6), as important inflammatory factors affecting hepatic steatosis, are mainly responsible for the induction of neutrophil sequestration in the liver and directly mediate tissue injury (67). Here, NFKB1 is linked to fatty liver disease.