INS and type 1 diabetes mellitus: The methanol extract of Ecklonia cava has shown to possess a radical scavenging activity and lowers blood glucose levels and enhances insulin concentration in type 1 diabetic rats by modulating AMPK activation and PI-3 kinase/Akt signal pathways (45), and these findings of EPE’s effects and mechanisms of action were similar to those of the methanol extract (45).