In the present study, administration of EPE to STZ-induced diabetic mice increased AMPK activation and expression levels of PPARα, but reduced SREBP1c and FAS, apo-CIII, and DGAT2 may at least in part explain the mode of action of EPE amelioration of the blood lipid disorders of STZ-induced T1DM by AMPK/PPARα or AMPK/SREBP1c/FAS observed. Here, PPARA is linked to type 1 diabetes mellitus.