AGER and Hyperglycemia: At the tissue level, RAGE activation in aortic macrophages increased interferon regulatory factor 7 (Irf7) and similarly reduced atherosclerosis regression in aortas from Ldlr−/− mice transplanted to WT or Ager−/− mice, suggesting that RAGE may act as an additional and important mechanism mediating the effects of hyperglycemia on diabetic atherosclerosis progression and regression [13,51,55].