In another study, Nezami et al. [112] evaluated plasma levels of several proteins formerly correlated with myocardial fibrosis (metalloproteinase inhibitor 4 (TIMP-4), ST-2, Gal-3, GDF-15, and matrix metalloproteinase 2, 3, and 9) in hospitalized patients with HF. This evidence concerns the gene TIMP4 and Myocardial fibrosis.