TARDBP and amyotrophic lateral sclerosis: Consistent with previous studies reporting increased DNA damage following TDP-43 depletion (Mitra et al., 2019; Konopka et al., 2020), we found elevated DNA damage in iPSCs generated from ALS patients with specific genetic mutations in TARDBP and in post-mitotic neurons differentiated from these iPSC lines, suggesting that these defects caused by mutant TDP-43 are not cell-type specific, indicating a molecular consequence of partial loss of TDP-43 function.