Compared with normal skin and scar tissue, M2 macrophages in keloid significantly increased (Direder et al., 2022; Feng et al., 2022), and promoted the proliferation and migration of skin fibroblasts by generating connective tissue growth factor and activating ERK1/2/STAT3 and AKT/STAT3 signaling pathways (Zhang et al., 2021). This evidence concerns the gene STAT3 and keloid.