Annexin A1 (AnxA1), a calcium-phospholipid-binding protein, can prevent the development of fibrosis in NASH by regulating liver macrophage differentiation from Trem2CD9 profibrotic macrophage to Kupffer cells (Gadipudi et al., 2022). The gene discussed is ANXA1; the disease is metabolic dysfunction-associated steatohepatitis.