ALOX15 and diabetes mellitus: Increased expression of Alox15 in the sciatic nerve of DM-induced mice was associated with enhanced oxidative stress and PARP activation, and compared to untreated wild-type mice with DM, these two phenomena were less present in Alox15−/− mice or Alox15-inhibitor-treated DM wild-type mice (Stavniichuk et al., 2010).