Many different types of cancer, including renal cell carcinoma, glioblastoma, thymic carcinoma, nasopharyngeal carcinoma, T-anaplastic large-cell lymphoma, Waldenström’s macroglobulinemia, and Hodgkin and non-Hodgkin lymphomas, may respond well to therapies that target CD70 (13, 15, 23–28). The gene discussed is CD70; the disease is hereditary clear cell renal cell carcinoma.