NLRP3 and neoplasm: The NLRP3–HSP70 axis recruits granulocytic polymorph-nuclear myeloid-derived suppressor cells (PMN-MDSCs; see above and (56, 58, 59)) into the tumor microenvironment, which are major regulators of tumor immune suppression and support disease hyperprogression in response to anti-PD-1 immunotherapy.