ADAM17 and cystic fibrosis: Supplementation of the CF-isolates with purified SpA led to increased ROS production at similar levels as generated following incubation with USA300 without additional SpA; and vice versa, inhibition of ADAM17 in neutrophils incubated with USA300 reduced the ROS response to the levels of those neutrophils responding to the CF-isolates, supporting the hypothesis that SpA influences ROS generation through ADAM17 mediated L-selectin shedding.