NETs are large, extracellular, web-like structures composed of nuclear and mitochondrial DNA that form a scaffold for histones, neutrophil elastase, myeloperoxidase (MPO), calprotectin, cathelicidin, and other defensins to trap and kill bacteria, important defensive mechanisms in homeostasis and in disease; e.g., sepsis (13–15). This evidence concerns the gene MPO and Sepsis.