Figure 3F confirms that CD8+ T cells were critically required to mediate and prevent MC38 progression since animals rapidly succumbed to tumor challenge in the absence of a functioning cytotoxic T cell response. Altogether, the observed anti-tumor effects observed in αDC1-DLK1 vaccinated mice (Figure 2A) are presumably aided by improved infiltrating cytotoxic CD8+ T cells (cross-primed against various TME-associated antigens) functioning in a Type-I shifted immunological environment. This evidence concerns the gene CD8A and neoplasm.