Lately, Gu and co-authors (Gu et al., 2021) discovered that MSCs-derived exosome could suppress hepatocellular cancer stem cells (CSCs) malignancy through a long noncoding RNAs (lncRNAs) C5orf66-AS1/micro-RNA-127-3p/dual-specificity phosphatase 1 (DUSP1)/ERK axis. The gene discussed is DUSP1; the disease is hepatocellular carcinoma.