A unique tumor-associated vasculature is activated through a variety of mechanisms, including an increased level of reactive oxygen spices (ROS) and activation of mechanistic target of rapamycin (mTOR) pathway (Quail and Joyce, 2013; Chaurasia et al., 2016; Hu et al., 2016; Manier et al., 2016; Schulz et al., 2019). Here, MTOR is linked to neoplasm.