While several PRRs are known to trigger inflammasome formation (Franchi et al., 2009; Kelley et al., 2019), the fibroproliferative role of the NLRP3 (NOD [nucleotide-binding oligomerization domain], LRR [leucine-rich repeat] containing proteins, and PYD-3 [pyrin domain-containing protein-3]) inflammasome has been of significant interest in SSc-ILD. Here, NLRP3 is linked to systemic sclerosis.