Furthermore, PDB extracts promoted the expression of insulin receptor β (IRβ), insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), and glucose transporter-4 (GLUT4) in the liver to enhance insulin sensitivity and reduce insulin resistance (Hu et al., 2014; Kong et al., 2021). Here, SLC2A4 is linked to Insulin resistance.