IL6 and colitis: It is significant that isoliquiritigenin is predominantly found in the gastrointestinal tract and has the potential to reduce the severity of dextran sulfate sodium-induced colitis by inhibiting the MAPK pathway (Choi et al., 2016) and preventing colitis-related tumors by preventing the polarization of macrophage M2 by prostaglandin E2 and interleukin-6 (IL-6).