Serum proteomic profiling of patients with breast cancer using a separation protocol in which peptides bound to a carrier protein were isolated by affinity chromatography by MBs and subjected to MALDI-TOF MS analysis has also identified 3 peptide biomarkers (FGA 605-629, ITIH4 347-356, and APOA2 43-52) for breast cancer diagnosis and prognosis [141]. This evidence concerns the gene APOA2 and breast carcinoma.