This delay is consistent with the symptoms observed, which for immediate related AEs are mainly due to complement activation (by aggregates, kallikreins, or stabilizing agents present in IVIg preparations), such as flu-like syndromes (including headache, nausea, fever, asthenia, cough, etc.)or dermatological symptoms (eczema) (3). Here, KLK4 is linked to Eczematoid dermatitis.