Further conventional (2D) in vitro assays for tumor growth‐ and metastasis‐related TC features revealed inconsistent results, which were only partially in line with the in vivo observations: upon CD44 kd, HT‐29 TC proliferation was increasingly improved over time (Fig. S5A), cell migration was enhanced (Fig. S5B), and invasion was decreased (Fig. S5C). This evidence concerns the gene CD44 and neoplasm.