With the persistent and fluctuating functional decline of the ovary, the clinical state in patients with POI progresses from occult (with normal FSH levels, reduced fecundity and regular menses) to biochemical (with elevated FSH levels, reduced fecundity and regular menses) to overt (with elevated FSH levels, reduced fecundity and irregular or absent menses, also termed premature ovarian failure, POF) [9]. This evidence concerns the gene BRD2 and premature menopause.