IL10 and Rotavirus infection: The results also showed that long-term aspirin administration lowered the expression levels of IL2 and IL10 in rotavirus infection rats.IL-10 was considered a master negative regulator of inflammation and a key component of cytokine system that regulated and suppressed the expression of proinflammatory cytokines during the recovery phases of infections and consequently reduced the damage caused by inflammatory cytokines [51, 52].Interleukin-2 (IL-2) was considered to be an essential growth factor for T cells and was implicated in initiating immune responses.