PTGS1 and Rotavirus infection: Rotavirus infection was attenuated by a nonspecific COX inhibitor, and a COX-1/COX-2-specific inhibitor [47, 48].We found that adding aspirin 12 h after rotavirus infection inhibited the expression of COX-2 in host cells, and after 24 h, compared with the RV infection group, the mRNA COX-2 expression increased, while the activity of PGE2 was statistically insignificant.