PTGS1 and Rotavirus infection: Previous studies have shown that rotavirus infection of Caco-2 cells increases the expression of COX-2 mRNA and the secretion of PGE2 prostaglandin [41].As a key feature of its mechanism, aspirin inhibits prostaglandin synthesis by irreversibly inactivating cyclo-oxygenase 1 and 2 (COX-1 and COX-2) [42]; Therefore, we evaluated the effects of aspirin on COX-2 and PGE2 in host cells.